Protim co-signe un article dans Journal of Proteome Research sur la découverte de 4 nouvelles "missing proteins"

? Protim co-signe un article dans Journal of Proteome Research sur la découverte de 4 nouvelles "missing proteins" contribuant ainsi, à nouveau, au "Chromose-centric Human Proteome Project" C-HPP.

? https://lnkd.in/eEiuQKMk

ABSTRACT: The Chromosome-centric Human Proteome Project (C-HPP) aims at
identifying the proteins as gene products encoded by the human genome, characterizing
their isoforms and functions. The existence of products has now been confirmed for
93.2% of the genes at the protein level. The remaining mostly correspond to proteins of
low abundance or di!cult to access. Over the past years, we have significantly
contributed to the identification of missing proteins in the human spermatozoa. We
pursue our search in the reproductive sphere with a focus on early human embryonic
development. Pluripotent cells, developing into the fetus, and trophoblast cells, giving
rise to the placenta, emerge during the first weeks. This emergence is a focus of
scientists working in the field of reproduction, placentation and regenerative medicine.
Most knowledge has been harnessed by transcriptomic analysis. Interestingly, some
genes are uniquely expressed in those cells, giving the opportunity to uncover new
proteins that might play a crucial role in setting up the molecular events underlying
early embryonic development. Here, we analyzed naive pluripotent and trophoblastic
stem cells and discovered 4 new missing proteins, thus contributing to the C-HPP. The mass spectrometry proteomics data was
deposited on ProteomeXchange under the data set identifier PXD035768.
KEYWORDS: human proteome project, missing proteins, human naive pluripotent stem cells, human trophoblastic stem cells