ImPACcell ImPACcell a développé un modèle de tumeur sur le Zebrafish ...

ImPACcell a développé un modèle de tumeur sur le Zebrafish ...

ImPACcell a développé un modèle de tumeur sur le zebrafish afin de confirmer in vivo l'effet de l'herbicide DCMU sur les fonctions des lymphocytes T en modulant les profils d'expression des microRNA.

 

? https://doi.org/10.3389/fimmu.2022.925241

 

 

Figure 5 DCMU exposures create a permissive environment to tumor development. (A) Schematic diagram of the experimental design. (B) Percent of GFP+ larvae. In black, zebrafish injected with M113 cells alone, in dark green, zebrafish injected with M113 and CTL03.1 cells exposed to vehicle and in red, zebrafish co-injected with M113 and CTL03.1 cells exposed to DCMU (250 µM). (C) Quantification of GFP+ spots per larvae. In black, zebrafish injected with M113 cells alone, in darkgreen, zebrafish co-injected with M113 and CTL03.1 cells exposed to vehicle and in red, zebrafish co-injected with M113 and CTL03.1 cells exposed to DCMU (250μM).(D) Representative lateral view of zebrafish larvae bearing M113 cells (green) in the three groups. Zoom 2.5 x. Mean of 3 independent experiments, n=8 larvae per group, per experiment. Statistical significance. * p≤.05, ** p≤0.01, *** p≤0.001. **** p≤0.0001.